Standardization of Melphalan Administration
نویسندگان
چکیده
منابع مشابه
Intraarterial administration of melphalan for treatment of intracranial human glioma xenografts in athymic rats.
Malignant gliomas will affect 15,000-17,000 Americans each year and carry a dismal prognosis. Adjuvant chemotherapy is hampered by inadequate drug delivery, systemic toxicity, and a markedly variable biological sensitivity. Intraarterial (i.a.) therapy may enhance selectivity by improving tumor drug delivery and reducing systemic toxicity. Using melphalan given i.a., we studied the therapy of i...
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Methods |After obtaining informed consent, 3 bilateral superselective intraophthalmic artery chemotherapy treatments were performed 1 month apart, following a previously described protocol.1 Each infusion consisted of 2.5 mg of melphalan in30mLof salineat a rate of 1 mL/min for 30 minutes per eye. ARetCam 1300 lens (Clarity Medical Systems) was used to take serial fundus photographs and videos....
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Immunization of cancer patients is most effective in tumor-free conditions or in the presence of minimal residual disease. In the attempt to develop new strategies able to control tumor recurrence while allowing the development of protective immunity, we have investigated the immunogenic potential of two distinct vaccine formulations when provided alone or upon single and repeated treatment wit...
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BACKGROUND High-dose chemotherapy followed by autologous hematopoietic stem-cell transplantation has been reported to provide higher response rates and better overall survival than standard chemotherapy in immunoglobulin-light-chain (AL) amyloidosis, but these two strategies have not been compared in a randomized study. METHODS We conducted a randomized trial comparing high-dose intravenous m...
متن کاملMelphalan therapy of polycythemia vera.
Twenty-seven patients with p. vera and adverse hematologic effects were whose proliferative disease required the infrequent. To date one patient has desuppression of bone marrow function veloped refractory anemia and evidence were treated with melphalan for periods of myelofibrosis. Four patients have deof 20 to 72 months. The response was veloped acute leukemia but none of these rated as good ...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2012
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2011.12.462